The Nobel Prize committee on Monday awarded the 2019 Nobel Prize for Physiology or Medicine to scientists William G. Kaelin, Jr, Peter J. Ratcliffe and Gregg L. Semenza.

The trio were jointly awarded for their discoveries of “how cells sense and adapt to oxygen availability,” the Nobel Committee announced Monday.

The discoveries made by the three men “have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases,” the Committee added.

Two of the scientists, Kaelin and Semenza, are U.S.-based, at Harvard University and Johns Hopkins respectively while Ratcliffe, is based at the Francis Crick Institute in London.

This is the 110th prize in the medicine category that has been awarded since 1901.

The Karolinska Institute in statement said the trio should share equally the 9 million kronor ($918,000) cash award.